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KMID : 1140120100150030181
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Cancer Prevention Research
2010 Volume.15 No. 3 p.181 ~ p.184
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A Composite Peripheral T-Cell Lymphoma and Anaplastic Variant of Diffuse Large B-Cell Lymphoma
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Lee Jong-Sil
Ko Gyung-Hyuck
Yang Jung-Wook
Kim Dong-Chool
Lee Jeong-Hee
Lee Gyeong-Won
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Abstract
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We report a rare case of a composite lymphoma consisting of peripheral T-cell lymphoma (PTCL), not otherwise specified (NOS), and an anaplastic variant of diffuse large B-cell lymphoma (DLBCL) associated with Epstein-Barr virus (EBV) infections in the 47-year-old man. The patient initially sought care at a local hospital with a single enlarged cervical lymph node. Histologic examination disclosed EBV-associated PTCL. Chemotherapy and autologous stem cell transplantation resulted in complete remission. After 5 years, the patient was readmitted due to generalized lymphadenophathy. The biopsy of the cervical lymph node showed PTCL. He underwent chemotherapy treatment, but an inguinal lymph node grew in size. The lymph node showed partial involvement of DLBCL in addition to PTCL. Many lymphocytes in the B-cell lymphoma and T-cell lymphoma showed positivity for EBV. This case suggests that EBV may have contributed to the development of a composite EBV-associated B-cell lymphoma and T-cell lymphoma.
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KEYWORD
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Peripheral T-cell lymphoma, Diffuse, Large B-Cell, Lymphoma, Epstein-Barr virus infections
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